Harvard Medical School
Brigham and Women's Hospital
 
 
 
 
 
 
Selective Publications



Jing Zhou. Polycystins and Primary Cilia: Primers for Cell Cycle Progression. Annual Review of Physiology 71:83-113, 2009

Ayumi Takakura, Leah Contrino, Xiangzhi Zhou, Joseph V. Bonventre, Yanping Sun, Benjamin D. Humphreys and Jing Zhou. Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Human Molecular Genetics 2009, Vol. 18, No. 14 2523–2531 supplemental data

Takakura A, Contrino L, Beck A, and Zhou J. Pkd1 Inactivation Induced in Adulthood Produces Focal Cystic Disease. J Am Soc Nephrol, 19(12):2351-63. Epub 2008 Sep 5.

G. V. Z. Dedoussis, Y. Luo, P. Starremans, S. Rossetti, A. J. Ramos, H. F. Cantiello, E. Katsareli, P. Ziroyannis, K. Lamnissou, P. C. Harris and J. Zhou. Co-inheritance of a PKD1 mutation and homozygous PKD2 variant: a potential modifier in autosomal dominant polycystic kidney disease. Eur J Clin Invest 38 (3): 180–190,2008

Elona Kolpakova-Hart, Claudia Nicolae, Jing Zhou, Bjorn R. Olsen. Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes. Matrix Biology 27:505–512, 2008

Surya M. Nauli, Yoshifumi Kawanabe, John J. Kaminski, William J. Pearce, Donald, E. Ingber and Jing Zhou. Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1. Circulation 117;1161-1171, 2008

PG Starremans, X Li, PE Finnerty, L Guo, A Takakura, EG Neilson and J Zhou. A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 50 end of Pkd1. Kidney International 73, 1394–1405, 2008

Sohara E, Luo Y, Zhang JJ, Qiu H, Beier DR and Zhou J. Nek8 kinase regulates the ciliary expressions and localizations of polycystin-1 and polycystin-2. MOLECULAR AND CELLULAR BIOLOGY 2007:6383–6395

Yu Tian, Robert Kolb, Jeong-Ho Hong, John Carroll, Dawei Li, John You, Roderick Bronson, Michael B. Yaffe, Jing Zhou, and Thomas Benjamin1. TAZ Promotes PC2 Degradation through a SCFb-Trcp E3 Ligase Complex. J Am Soc Nephrol 19: 469–476, 2008.

Wang SX, Zhang JJ, Nauli SM, Li X, Starremans P, Luo Y, Roberts KA, Zhou J. Fibrocystin is associated with polycystin-2 and regulates intracellular calcium concentration. Mol Cell Biol. 27(8):3241-52, 2007.

Cherie Stayner, Diana M. Iglesias, Paul R. Goodyer, Lana Ellis, Greg Germino,Jing Zhou4 and Michael R. Eccle. Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease. Human Molecular Genetics 2006: 3520–3528, 2008.

Nauli SM, Rossetti S, Kolb RJ, Alenghat AJ, Harris PC, Ingber DE, Loghman-Adham M, Zhou J, Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol, 2006, Apr;17(4):1015-25

Li XG, Luo Y, Starremans P, McNamara CA, Pei Y, and Zhou J. Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol, 2005 Dec;7(12):1102-12. Epub 2005 Nov 27.    Commentary in Nat Cell Biol

Yuasa T, Takakura A, Denker BM, Venugopal B, and Zhou J. Polycystin-1L2 is a novel G-protein binding protein. Genomics, 2004 Jul;84(1):126-38.

Delmas P, Nauli SM, Li X, Lakkis M, Luo Y, Elia A, Williams E, Frischauf AM, Crest M, Brown DA and Zhou J. Gating of the polycystin channel complex by conformational change of polycystin-1. FASEB, 2004 Apr;18(6):740-2.

Wang S, Luo Y, Wilson PD, Witman G, Zhou J. Autosomal recessive polycystic kidney disease protein is concentrated in the basal body area of primary cilia. J Am Soc Nephrol 2004 Mar;15(3):592-602.

Herzog C, Zhuang LY, Gorgan, L, Segal Y, and Zhou J. Identification of cis-regulatory elements that contribute to tissue- and site-specific a5(IV) and a6(IV) collagen expression in vivo. Biochem Biophys Res Commun 2003, Nov 14;311(2):553-60.

Loghman-Adham M, Nauli S, Soto CE, Kariuki B, and Zhou J. Immortalized epithelial cells from human autosomal dominant polycystic kidney cysts. Am J Physiol 2003, Sep;285(3):F397-412.

Luo Y, Vassilev P, Li X, Kanawabe Y, and Zhou J. Native polycystin-2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol Cell Biol, 2003 Apr;23(7):2600-7.

Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AEH, Lu W, Brown EM, Quinn SJ, Ingber DE, and Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nature Genetics (Article), 2003 Feb;33(2):129-37.    Commentary in Nat Genet. 2003 Feb;33(2):113-4.

Yuasa T, Venugopal B, Weremowicz S, Morton CC, Guo L, and Zhou J. A Novel Polycystic Kidney Disease 1 Like Gene, PKD1L1, in Human: Sequence, Expression, and Chromosomal Localization. Genomics, 2002 Mar;79(3):376-86.

Delmas P, Nomura H, Li X, Lakkis M, Luo Y, Segal Y, Fernández-Fernández J, Harris P, Frischauf AM, Brown DA and Zhou J. Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J. Biol. Chem, 2002, Mar 29;277(13):11276-83.

Basora N, Nomura H, Berger U, Stayner C, Guo L, Shen XH, and Zhou J. Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L. J Am Soc Nephrol 2002 Feb;13(2):293-301.

Lu WN, Shen X, Pavlova A, Lakkis M, Ward C, Pritchard L, Harris P, Genest D, Perez-Atayde A, and Zhou J. Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects. Hum Mol Genetics. 2001, Oct 2;10(21):2385-2396.

Vassilev P, Guo L, Chen XZ, Segal Y, Peng JB, Basora N, Babakhanlou H, Cruger G, Kanazirska M, Ye CP, Brown EM, Hediger MA, and Zhou J. Polycystic kidney disease 2 gene encodes a novel high conductance channel implicated in defective intracellular Ca2+ homeostasis. Biochem Biophys Res Commun 2001, Mar 23;282(1):341-350.

Chen XZ, Segal Y, Basora N, Guo L, Peng JB, Babakhanlou H, Vassilev P, Brown EM, Hediger MA, and Zhou J. The transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X. Biochem Biophys Res Commun 2001 Apr 20;282(5):1251-6.

Segal Y, Rondeau E and Zhou J. Identification of cis-acting elements and promoter configuration of the type IV collagen gene COL4A5 and COL4A6. J. Biol. Chem, 2001 Apr 13;276(15):11791-7.

Guo L, Schreiber TH, Weremowicz S, Morton CC, and Zhou J. Molecular cloning and characterization of a novel polycystin family member, polycystin-l2, in mouse and man. Genomics. 2000, Mar:64,241-251.

Guo, L, Chen, MH, Basora, N, and Zhou, J. The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism. Mammalian Genome, 2000 Jan;11(1):46-50.

Chen, XZ, Vassilev, PM, Basora, N, Peng, JP, Nomura, N, Segal, Y, Brown, EB, Reeders, ST, Hediger, MA, and Zhou, J. Polycystin-L, a member of the polycystin family of proteins, is a calcium-permeable cation channel. Nature, 1999, 401, 383-386.

Lu WN, Fan XH, Basora N, Babakhanlou H, Law T, Rifai N, Harris PC, Perez-Atayde AR, Rennke HG and Zhou J. Late onset of renal and hepatic cysts in mice heterozygous for a Pkd1 mutation. Nature Genetics 1999, 21(2):160-161.

Segal Y, Peissel B, Renieri A, de Marchi M, Ballabio A, Pei Y, and Zhou J: Line-1 elements at the sites of molecular rearrangements in Alport syndrome-diffuse leiomyomatosis, Am J Hum Genet 1999 Jan;64(1):62-9.

Nomura H, Turco AE, Pei Y, Kalaydjieva L, Weremowicz S, Ji W, Morton C, Meisler M, Reeders, ST, and Zhou J. Identification of PKDL, a novel polycystic kidney disease 2-like gene, whose murine homologue is deleted in mice with kidney and retinal defects. J. Biol. Chem, 1998, 273(40):25967-25973.

Geng L, Segal Y, Pavlova A, Barros EJG.; Löhning C, Lu W, Nigam S.K, Frischauf AM, Reeders ST and Zhou J. Distribution and developmentally regulated expression of murine polycystin. Am J Physiol, F451-F459, 1997.

Lu WN, Peissel B, Babakhanlou H, Fan XH, Pavlova A, Geng L, Larson C, Brent G, and Zhou J. Perinatal lethality and defects with kidneys and pancreas defects in mice with targeted Pkd1 mutations. Nature Genetics, 1997; 17:179-181.

Geng L, Segal Y, Peissel B, Deng N, Pei Y, Carone F, Rennke HG, Glucksmann-Kuis S, Schneider MC, Ericsson M, Reeders ST and Zhou J. Identification and Localization of Polycystin, the PKD1 Gene Product. J Clin Invest. 1996; 98:2674-2682.

International PKD Consortium. Polycystic kidney disease: The complete structure of the PKD1 gene and its protein. Cell. 1995; 81: 289-298.

Peissel, B, Geng L, Kalluri R, Kashtan K, Rennke HG, Gallo GR, Sun MJ, Hudson BG, Neilson EG and Zhou J. Comparative distribution of the a1(IV), a5(IV) and a6(IV) collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients. J Clin Invest. 1995; 96: 1948-1957.

Zhou J, Ding M, Zhao ZH, and Reeders ST. Complete Primary Structure of the Sixth Chain of Human Basement Membrane Collagen, a6(IV). Isolation of the cDNAs for a6(IV) and comparison with five other type IV collagen chains. J Biol Chem, 1994; 269:13193-13199.

Zhou J, Leinonen A and Tryggvason K. Structure of the human type IV collagen COL4A5 gene. J Biol Chem, 1994; 269:6608-6614.

Zhou J, Mochizuki T, Smeets H, Antignac C, Tryggvason K, Reeders S. Deletion of paired a5(IV) and a6(IV) collagens in an inherited smooth muscle tumor. Science, 1993; 261:1167-1169.

Zhou J, Gregory MC, Hertz JM, Barker DF, Atkin C, Spencer E, Tryggvason K. Mutations in the codon for a conserved arginine-1563 in three unrelated families with Alport syndrome. Kidney Int 1993; 43:722-9.

Zhou J, Hertz JM, Leinonen A, Tryggvason K. Complete amino acid sequence of the human a5(IV) collagen chain and identification of a single base mutation in exon 23 converting glycine-521 in the collagenous domain to cysteine in an Alport syndrome patient. J Biol Chem 1992; 267:12475-81.

Zhou J, Hertz JM, Tryggvason K. Mutation in the a5(IV) collagen chain in juvenile-onset Alport syndrome without hearing loss of ocular lesions: Detection by denaturing gradient gel electrophoresis of a PCR product. Am J Human Genet 1992; 50:1291-1300.

Zhou J, Barker D, Hostikka SL, Gregory M, Atkin C, Tryggvason K. Single base mutation in a5(IV) collagen chain gene converting a conserved cysteine to serine in Alport syndrome. Genomics 1991; 9:10-18.

Zhou J, Hostikka SL, Chow LT, Tryggvason K. Characterization of the 3’ half of the human type IV collagen a5 gene which is affected in Alport syndrome. Genomics 1991; 9:1-9.

Barker D, Hostikka SL, Zhou J, Chow LT, Oliphant AR, Gerken SC, Gregory MC, Skolnick MH, Atkin CL, Tryggvason K. Identification of mutations in the COL4A5 collagen gene in Alport syndrome. Science 1990; 248:1224-7.