Harvard Medical School
Brigham and Women's Hospital
 
 
 
 
 
Selective Publications



2012

Qin S, Taglienti M, Cai L, Zhou J, Kreidberg JA. c-Met and NF-κB-Dependent Overexpression of Wnt7a and -7b and Pax2 Promotes Cystogenesis in Polycystic Kidney Disease. J Am Soc Nephrol 23, 1309-1318. 2012 Jun 7. [Epub ahead of print].

Subramanian, B., Ko, W.C., Yadav, V., Desrochers, T.M., Perrone, R.D., Zhou, J., and Kaplan, D.L. The regulation of cystogenesis in a tissue engineered kidney disease system by abnormal matrix interactions. Biomaterials. 2012, 1-13.

Yao G, Luyten A, Takakura A, Plomann M, and Zhou J. The cytoplasmic protein Pacsin 2 in kidney development and injury repair. Kidney Int. 2012 Dec 12. [Epub ahead of print].

2011

Takakura A, Nelson EA, Humphreys BD, Zandi-Nejad K, Frank DA, Zhou J. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum Mol Genet. 2011

Zhou, J., Chang, M., Signoretti, S., & Kaelin, W. Genetic and Functional Studies Implicate HIF1a as a 14q Kidney Cancer Suppressor Gene. Cancer Discovery. 2011

Pandey P, Qin S, Ho J, Zhou J, Kreidberg JA. Systems biology approach to identify transcriptome reprogramming and microRNA targets during the progression of Polycystic Kidney Disease. BMC Syst Biol. 2011 Apr 25;5(1):56. [Epub ahead of print] 2011

2010

Zhou X, Bao H, Takakura A, Zhou J, Albert M, Sun Y. Polycystic kidney disease evaluation by magnetic resonance imaging in ischemia-reperfusion injured PKD1 knockout mouse model: comparison of T2-weighted FSE and true-FISP. Invest Radiol, 2010 vol. 45 (1) pp. 24-8

Besschetnova TY, Kolpakova-Hart E, Guan Y, Zhou J, Olsen BR, Shah JV. Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Current Biology. 2010 Jan 26;20(2):182-7. Epub 2010 Jan 21.

Subramanian B, Rudym D, Cannizzaro C, Peronne R, Zhou J, Kaplan DL. Tissue Engineered 3D in vitro Models for Normal and Diseased Kidney. Tissue Eng Part A. 2010 Sep;16(9):2821-31.

Luyten A, Su X, Gondela S, Chen Y, Takakura A, Zhou J. Aberrant regulation of planar cell polarity pathway in human and mouse polycystic kidney disease. J Am Soc Nephrol Sep;21(9):1521-32. Epub 2010 Aug 12.

Zhang J, Wu M, Wang S, Shah J, Wilson PD, Zhou, J. Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity. Hum Mol Genet, Sep 1;19(17):3306-19. Epub 2010 Jun 16.

Yu W, Ritchie BJ, Su X, Zhou J, Meigs TE, Denker BM. Identification of polycystin-1 and Ga12 binding regions necessary for regulation of apoptosis. Cell Signal. 2011 Jan;23(1):213-21. Epub 2010 Sep 17.

Qin S, Taglienti M, Nauli SM, Contrino L, Takakura A, Zhou J, Kreidberg JA. Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease. J Clin Invest. 2010 Oct 1;120(10):3617-28. doi: 10.1172/JCI41531. Epub 2010 Sep 13.

2009

Jing Zhou. Polycystins and Primary Cilia: Primers for Cell Cycle Progression. Annual Review of Physiology 71:83-113, 2009

Ayumi Takakura, Leah Contrino, Xiangzhi Zhou, Joseph V. Bonventre, Yanping Sun, Benjamin D. Humphreys and Jing Zhou. Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Human Molecular Genetics 2009, Vol. 18, No. 14 2523?531 supplemental data

Zhang P, Luo Y, Gonzalez-Perrett S, Montalbetti N, Timpanaro G, Cantero M, Ramos A, Goldmann W, Zhou J, Cantiello H. The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and heteromultimers with TRPC1. Hum Mol Genet, 2009, Apr 1;18(7):1238-51. Epub 2009 Feb 3

Kong T, Xu D, Yu W, Takakura A, Boucher I, Tran M, Kreidberg JA, Shah J, Zhou J, Denker BM. G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-i and blocks tubulogenesis. Mol Biol Cell, 2009 vol. 20 (21) pp. 4596-610

2008

Takakura A, Contrino L, Beck A, and Zhou J. Pkd1 Inactivation Induced in Adulthood Produces Focal Cystic Disease. J Am Soc Nephrol, 19(12):2351-63. Epub 2008 Sep 5.

G. V. Z. Dedoussis, Y. Luo, P. Starremans, S. Rossetti, A. J. Ramos, H. F. Cantiello, E. Katsareli, P. Ziroyannis, K. Lamnissou, P. C. Harris and J. Zhou. Co-inheritance of a PKD1 mutation and homozygous PKD2 variant: a potential modifier in autosomal dominant polycystic kidney disease. Eur J Clin Invest 38 (3): 180?90,2008

Elona Kolpakova-Hart, Claudia Nicolae, Jing Zhou, Bjorn R. Olsen. Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes. Matrix Biology 27:505?12, 2008

Surya M. Nauli, Yoshifumi Kawanabe, John J. Kaminski, William J. Pearce, Donald, E. Ingber and Jing Zhou. Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1. Circulation 117;1161-1171, 2008

PG Starremans, X Li, PE Finnerty, L Guo, A Takakura, EG Neilson and J Zhou. A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 50 end of Pkd1. Kidney International 73, 1394?405, 2008

2007

Sohara E, Luo Y, Zhang JJ, Qiu H, Beier DR and Zhou J. Nek8 kinase regulates the ciliary expressions and localizations of polycystin-1 and polycystin-2. MOLECULAR AND CELLULAR BIOLOGY 2007:6383?395

Yu Tian, Robert Kolb, Jeong-Ho Hong, John Carroll, Dawei Li, John You, Roderick Bronson, Michael B. Yaffe, Jing Zhou, and Thomas Benjamin1. TAZ Promotes PC2 Degradation through a SCFb-Trcp E3 Ligase Complex. J Am Soc Nephrol 19: 469–476, 2008.

Wang SX, Zhang JJ, Nauli SM, Li X, Starremans P, Luo Y, Roberts KA, Zhou J. Fibrocystin is associated with polycystin-2 and regulates intracellular calcium concentration. Mol Cell Biol. 27(8):3241-52, 2007.

2006

Cherie Stayner, Diana M. Iglesias, Paul R. Goodyer, Lana Ellis, Greg Germino,Jing Zhou4 and Michael R. Eccle. Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease. Human Molecular Genetics 2006: 3520?528

Nauli SM, Rossetti S, Kolb RJ, Alenghat AJ, Harris PC, Ingber DE, Loghman-Adham M, Zhou J, Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol, 2006, Apr;17(4):1015-25

2005

Li XG, Luo Y, Starremans P, McNamara CA, Pei Y, and Zhou J. Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol, 2005 Dec;7(12):1102-12. Epub 2005 Nov 27.    Commentary in Nat Cell Biol

2004

Yuasa T, Takakura A, Denker BM, Venugopal B, and Zhou J. Polycystin-1L2 is a novel G-protein binding protein. Genomics, 2004 Jul;84(1):126-38.

Delmas P, Nauli SM, Li X, Lakkis M, Luo Y, Elia A, Williams E, Frischauf AM, Crest M, Brown DA and Zhou J. Gating of the polycystin channel complex by conformational change of polycystin-1. FASEB, 2004 Apr;18(6):740-2.

Wang S, Luo Y, Wilson PD, Witman G, Zhou J. Autosomal recessive polycystic kidney disease protein is concentrated in the basal body area of primary cilia. J Am Soc Nephrol 2004 Mar;15(3):592-602.

2003

Herzog C, Zhuang LY, Gorgan, L, Segal Y, and Zhou J. Identification of cis-regulatory elements that contribute to tissue- and site-specific a5(IV) and a6(IV) collagen expression in vivo. Biochem Biophys Res Commun 2003, Nov 14;311(2):553-60.

Loghman-Adham M, Nauli S, Soto CE, Kariuki B, and Zhou J. Immortalized epithelial cells from human autosomal dominant polycystic kidney cysts. Am J Physiol 2003, Sep;285(3):F397-412.

Luo Y, Vassilev P, Li X, Kanawabe Y, and Zhou J. Native polycystin-2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia. Mol Cell Biol, 2003 Apr;23(7):2600-7.

Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AEH, Lu W, Brown EM, Quinn SJ, Ingber DE, and Zhou J. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nature Genetics (Article), 2003 Feb;33(2):129-37.    Commentary in Nat Genet. 2003 Feb;33(2):113-4.

2002

Yuasa T, Venugopal B, Weremowicz S, Morton CC, Guo L, and Zhou J. A Novel Polycystic Kidney Disease 1 Like Gene, PKD1L1, in Human: Sequence, Expression, and Chromosomal Localization. Genomics, 2002 Mar;79(3):376-86.

Delmas P, Nomura H, Li X, Lakkis M, Luo Y, Segal Y, Fern?dez-Fern?dez J, Harris P, Frischauf AM, Brown DA and Zhou J. Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2. J. Biol. Chem, 2002, Mar 29;277(13):11276-83.

Basora N, Nomura H, Berger U, Stayner C, Guo L, Shen XH, and Zhou J. Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L. J Am Soc Nephrol 2002 Feb;13(2):293-301.

2001

Lu WN, Shen X, Pavlova A, Lakkis M, Ward C, Pritchard L, Harris P, Genest D, Perez-Atayde A, and Zhou J. Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects. Hum Mol Genetics. 2001, Oct 2;10(21):2385-2396.

Vassilev P, Guo L, Chen XZ, Segal Y, Peng JB, Basora N, Babakhanlou H, Cruger G, Kanazirska M, Ye CP, Brown EM, Hediger MA, and Zhou J. Polycystic kidney disease 2 gene encodes a novel high conductance channel implicated in defective intracellular Ca2+ homeostasis. Biochem Biophys Res Commun 2001, Mar 23;282(1):341-350.

Chen XZ, Segal Y, Basora N, Guo L, Peng JB, Babakhanlou H, Vassilev P, Brown EM, Hediger MA, and Zhou J. The transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X. Biochem Biophys Res Commun 2001 Apr 20;282(5):1251-6.

Segal Y, Rondeau E and Zhou J. Identification of cis-acting elements and promoter configuration of the type IV collagen gene COL4A5 and COL4A6. J. Biol. Chem, 2001 Apr 13;276(15):11791-7.

2000

Guo L, Schreiber TH, Weremowicz S, Morton CC, and Zhou J. Molecular cloning and characterization of a novel polycystin family member, polycystin-l2, in mouse and man. Genomics. 2000, Mar:64,241-251.

Guo, L, Chen, MH, Basora, N, and Zhou, J. The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism. Mammalian Genome, 2000 Jan;11(1):46-50.

1999

Chen, XZ, Vassilev, PM, Basora, N, Peng, JP, Nomura, N, Segal, Y, Brown, EB, Reeders, ST, Hediger, MA, and Zhou, J. Polycystin-L, a member of the polycystin family of proteins, is a calcium-permeable cation channel. Nature, 1999, 401, 383-386.

Lu WN, Fan XH, Basora N, Babakhanlou H, Law T, Rifai N, Harris PC, Perez-Atayde AR, Rennke HG and Zhou J. Late onset of renal and hepatic cysts in mice heterozygous for a Pkd1 mutation. Nature Genetics 1999, 21(2):160-161.

Segal Y, Peissel B, Renieri A, de Marchi M, Ballabio A, Pei Y, and Zhou J: Line-1 elements at the sites of molecular rearrangements in Alport syndrome-diffuse leiomyomatosis, Am J Hum Genet 1999 Jan;64(1):62-9.

1998

Nomura H, Turco AE, Pei Y, Kalaydjieva L, Weremowicz S, Ji W, Morton C, Meisler M, Reeders, ST, and Zhou J. Identification of PKDL, a novel polycystic kidney disease 2-like gene, whose murine homologue is deleted in mice with kidney and retinal defects. J. Biol. Chem, 1998, 273(40):25967-25973.

1997

Geng L, Segal Y, Pavlova A, Barros EJG.; L?ning C, Lu W, Nigam S.K, Frischauf AM, Reeders ST and Zhou J. Distribution and developmentally regulated expression of murine polycystin. Am J Physiol, F451-F459, 1997.

Lu WN, Peissel B, Babakhanlou H, Fan XH, Pavlova A, Geng L, Larson C, Brent G, and Zhou J. Perinatal lethality and defects with kidneys and pancreas defects in mice with targeted Pkd1 mutations. Nature Genetics, 1997; 17:179-181.

1996

Geng L, Segal Y, Peissel B, Deng N, Pei Y, Carone F, Rennke HG, Glucksmann-Kuis S, Schneider MC, Ericsson M, Reeders ST and Zhou J. Identification and Localization of Polycystin, the PKD1 Gene Product. J Clin Invest. 1996; 98:2674-2682.

1995

International PKD Consortium. Polycystic kidney disease: The complete structure of the PKD1 gene and its protein. Cell. 1995; 81: 289-298.

Peissel, B, Geng L, Kalluri R, Kashtan K, Rennke HG, Gallo GR, Sun MJ, Hudson BG, Neilson EG and Zhou J. Comparative distribution of the a1(IV), a5(IV) and a6(IV) collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients. J Clin Invest. 1995; 96: 1948-1957.

1994

Zhou J, Ding M, Zhao ZH, and Reeders ST. Complete Primary Structure of the Sixth Chain of Human Basement Membrane Collagen, a6(IV). Isolation of the cDNAs for a6(IV) and comparison with five other type IV collagen chains. J Biol Chem, 1994; 269:13193-13199.

Zhou J, Leinonen A and Tryggvason K. Structure of the human type IV collagen COL4A5 gene. J Biol Chem, 1994; 269:6608-6614.

1993

Zhou J, Mochizuki T, Smeets H, Antignac C, Tryggvason K, Reeders S. Deletion of paired a5(IV) and a6(IV) collagens in an inherited smooth muscle tumor. Science, 1993; 261:1167-1169.

Zhou J, Gregory MC, Hertz JM, Barker DF, Atkin C, Spencer E, Tryggvason K. Mutations in the codon for a conserved arginine-1563 in three unrelated families with Alport syndrome. Kidney Int 1993; 43:722-9.

1992

Zhou J, Hertz JM, Leinonen A, Tryggvason K. Complete amino acid sequence of the human a5(IV) collagen chain and identification of a single base mutation in exon 23 converting glycine-521 in the collagenous domain to cysteine in an Alport syndrome patient. J Biol Chem 1992; 267:12475-81.

Zhou J, Hertz JM, Tryggvason K. Mutation in the a5(IV) collagen chain in juvenile-onset Alport syndrome without hearing loss of ocular lesions: Detection by denaturing gradient gel electrophoresis of a PCR product. Am J Human Genet 1992; 50:1291-1300.

1991

Zhou J, Barker D, Hostikka SL, Gregory M, Atkin C, Tryggvason K. Single base mutation in a5(IV) collagen chain gene converting a conserved cysteine to serine in Alport syndrome. Genomics 1991; 9:10-18.

Zhou J, Hostikka SL, Chow LT, Tryggvason K. Characterization of the 3?half of the human type IV collagen a5 gene which is affected in Alport syndrome. Genomics 1991; 9:1-9.

1990

Barker D, Hostikka SL, Zhou J, Chow LT, Oliphant AR, Gerken SC, Gregory MC, Skolnick MH, Atkin CL, Tryggvason K. Identification of mutations in the COL4A5 collagen gene in Alport syndrome. Science 1990; 248:1224-7.

 
 
 

PKD Syposium 2015

This year's PKD Symposium will be held on May 18 from 8:00 AM-5:00 PM in the Bray Room at the Joseph B. Martin Conference Center. Click here for registration and more information.

Click here to visit Harvard PKD Center website.